Common migraine symptoms and triggers

Migraine attacks show no mercy
You already know how painful a migraine attack can be – and that it’s more debilitating than "just a headache." You won’t always know when one will strike and each can be different than the next, making it difficult to treat. Migraine attacks last longer – from 4 to 72 hours – and may or may not have aura. If you experience flashes of light or blind spots, you may have migraine with aura. Throbbing pain on one or both sides of your head is only one symptom. Other migraine symptoms include:

Nausea
Vomiting
Sensitivity to light and/or sound
Visual effects and/or aura

What causes migraine?

Although what causes migraine is not exactly clear, it is believed that people who have migraine are more sensitive to their surroundings than others who do not. These conditions can affect the brain and may trigger an attack.

Triggers are things in your surroundings that could set off a migraine attack. Some people don’t have triggers, while others know their triggers and try to avoid them. They can be different for everyone, but certain foods or drinks, strong scents, or even hormones can be triggers. Other common triggers include:

Triggers include coffee, alcohol, stress, bright lights, loud sounds, perfume, smoke, weather, cheese, and missing sleep

How is migraine diagnosed?

Migraine is different for everyone, which can make diagnosing it difficult. If you experience head pain along with any of the symptoms mentioned above, tell your doctor.

Before your doctor can diagnose you with migraine, he or she will need some more information. Though physical exams are commonly used to help diagnose you, your doctor may also want to discuss your:

Family history

Having a history of migraine in your family can be a strong indicator of your own migraine experience.

Daily routine

There may be patterns in your daily routine that will help your doctor identify if you are coming in contact with common triggers. These triggers may be contributing to your migraine attack.

Attack experience

Different characteristics of attacks, such as how long they last, how close together they are, and other symptoms you experience in addition to pain, can help your doctor determine if you are experiencing a migraine attack.

What is an acute medicine?
Is it different from a preventive?

When learning about migraine medicines, you may have heard terms like “acute” and “preventive.” When you have a migraine, acute medicines like REYVOW are used to help get rid of the attack. Preventive medicines^* are used to help prevent attacks from happening in the first place.

^*REYVOW is not approved for the preventive treatment of migraine.

Learn more about a preventive treatment that could fit into your treatment plan. Talk to your doctor about what is right for you.

What kind of migraine medicine should I be taking?

Talk to your doctor about what migraine medicine is right for you. Your doctor may consider things like:

How many attacks you have each month
How severe your pain is

What your triggers are
Your daily activities

Remember, even if you are taking preventive medicine^*, you can still have a migraine attack. When one happens, you might benefit from an acute medicine (a medicine that helps when an attack happens).

Talk to your doctor to see if a medicine like REYVOW is right for you

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SAFETY SUMMARY

Warnings -

Do not drive or operate machinery for at least 8 hours after you take REYVOW, even if you feel well enough. You should not take REYVOW if you cannot wait at least 8 hours between taking REYVOW and driving or operating machinery.

You should not drink alcohol or take other medicines that make you drowsy while taking REYVOW.

REYVOW can cause serious side effects, including:

Medication overuse headache: People who take medicines to treat a migraine when it happens (acute treatments such as REYVOW) for 10 or more days each month can sometimes get worse headaches. If your headaches get worse, your doctor may stop your treatment.
Serotonin syndrome is a rare but serious problem that can happen to people who take REYVOW. This is more likely to happen if you take it with antidepressant medicines called SSRIs (selective serotonin reuptake inhibitors) or SNRIs (serotonin-norepinephrine reuptake inhibitors). Call your doctor right away if you have any of these symptoms:

mental changes, such as seeing things that are not there (hallucinations), agitation, or coma
fast heartbeat or changes in blood pressure
high body temperature
tight muscles
trouble walking
nausea, vomiting, or diarrhea

Common side effects
The most common side effects of REYVOW include dizziness, sleepiness, numbness, feeling tired, and tingling. These are not all the possible side effects of REYVOW. Tell your doctor if you have any side effects.

You can report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before You Take REYVOW:

Tell your doctor about all your medical conditions, including these:
❑ liver problems
❑ high blood pressure

❑ a low heart rate
❑ allergy to lasmiditan
Tell your doctor if you are pregnant or plan to become pregnant. Also tell your doctor if you are breastfeeding or plan to breastfeed.
❑ There is a pregnancy registry for women who take REYVOW. The purpose of this registry is to collect information about the health of you and your baby. You may enroll yourself by calling 1-833-464-4724 or by visiting www.migrainepregnancyregistry.com. Or you may talk to your doctor about how you can take part in this registry.
Tell your doctor about all prescription and over-the-counter medicines, vitamins, and herbal supplements you take. Especially tell your doctor if you take any of these:
❑ propranolol or other medicines that can lower your heart rate
❑ medicines that can increase blood pressure
❑ medicines that make you sleepy
❑ antidepressant medicines of these types:
- SSRIs or SNRIs
- TCAs (tricyclic antidepressants)
- MAOIs (monoamine oxidase inhibitors)

How to take

Take REYVOW exactly as your doctor tells you to, and do not change your dose without talking to your doctor. REYVOW should only be used during a migraine attack. It should not be used to try to prevent migraine attacks.

Take REYVOW tablets by mouth, with or without food.
Swallow REYVOW tablets whole. Do not split, crush, or chew them.
Do not take REYVOW more than one time within a 24-hour period. This means you must wait 24 hours between doses of REYVOW, even if your headache does not go away or goes away and comes back.

Learn more

REYVOW is a prescription medicine. For more information, call 1-833-REYVOW1 (1-833-739-8691).

This summary provides basic information about REYVOW but does not include all information known about this medicine. Read the information that comes with your prescription every time you have a prescription filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about REYVOW and how to take it. Your doctor is the best person to help you decide if REYVOW is right for you.

LM CON BS 14SEP2022

INDICATIONS

REYVOW^® (RAY-vow) is a medicine for adults used to treat migraine attacks with or without aura when they happen (acute treatment).

REYVOW is not used to prevent migraine attacks.
It is not known if REYVOW is safe and effective in children.
REYVOW is a federally controlled substance (C-V) because it contains lasmiditan that can be abused. Protect REYVOW from being stolen, and never give it to others because it may harm them. Selling or giving away REYVOW is illegal. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.
It is a tablet that you take by mouth.